First, click the icon on your desktop (or in the spyware utilities folder)
Click "yes" to allow it to update.
Wait for the update. This will usually take a while. You may want to make a cup of coffee.
When it finishes updating, it will usually want to restart the program. Click "yes".You will want to click "scan now"
Choose "quick scan", then "scan" at the bottom right.
Wait for the scan to complete.
When the scan finishes, it will show the items it found on a screen like this. Make sure everything has a check mark, then click "delete selected items". It will ask you to confirm that it's ok to delete these items. When it's done doing this, go ahead and close the program.