First, open the program with the icon on the desktop (or spyware utilities folder).
When the program opens, choose "run cleaner" at the bottom right. You may see a window after this warning you that the program is about to remove files and asking if it's ok. Go ahead and tell it to do so.
When it's done, it will show you a summary screen. You don't need to do anything at this point. Just close the program.