First, click the icon on your desktop (or in your spyware utilities folder)
This is the main program screen. You will want to check for updates first (button is at the bottom)
Wait for the update
Click "close" on this screen when the update finishes.
You'll end up back at the main screen. This time you will want to click "scan your computer"
As long as your actual hard drives are checked on the left (you don't need to scan cd drives), quick scan is fine on the right, you can go ahead and click "next".
Wait for the scan to finish
When the scan is done, it will either show you this screen, meaning you had no infections, or it will show you a list of the problems it found. If it shows you the list, make sure they are all checkmarked, and click "next" to remove them.